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Jamie Taylor

Jamie Taylor -

Last updated on Dec 21, 2023

Best CBD For Inflammation: Scientific Background, Effectiveness, and Top Products

Inflammation deprives millions of people of enjoying healthy and happy lives. Studies show that most chronic conditions like diabetes, obesity, cardiovascular, and autoimmune diseases involve systemic inflammation.

Worse yet, these ailments cause most deaths today. So what is inflammation, and how to protect your body from the involved risks of CBD? How to obtain the best CBD for inflammation? Read further to check this all out.

cbd oil for inflammation

What Is Inflammation?

Inflammation is the way your body defends itself from malicious agents, like viruses, bacteria, and microorganisms. When some agents enter your body, your immune cells and signaling molecules (pro-inflammatory cytokines) intercept and kill the invaders.

This process involves increased blood flow to the affected area (a wound, for example), resulting in pain, redness, and swelling. It’s called acute inflammation, which is a healthy body reaction, for the most part. However, there might also be chronic inflammation that can last for years, putting immense strain on your body. How to detect it then? Here are several chronic inflammation symptoms:

  • Fatigue.
  • Insomnia.
  • Anxiety and depression.
  • Chronic pain.
  • CBD for sleep
  • Diarrhea and other digestive disorders.

Nonetheless, visiting your practitioner and taking your tests are the best way to detect chronic inflammation. So how can CBD help you soothe your condition? Check this out below.

Does CBD Oil Help with Inflammation?

CBD, or cannabidiol, is a molecule extracted from cannabis plants. It has plenty of scientifically proven beneficial properties, including anti-inflammatory effects. In which way does CBD combat inflammation? Cannabidiol interacts with the endocannabinoid system (ECS), present in humans and other mammal species.

CBD is revealed to bind to many receptors involved in regulating the cellular inflammatory response.

Due to this, cannabidiol lowers pro-inflammatory cytokines release, preventing inflammation development. Thus, CBD binds to the TRPV1 receptor (one of several inflammation response regulators) and desensitizes it. Once blocked, the TRPV1 receptor can’t activate pro-inflammatory cytokines (such as tumor necrosis factor (TNF) or interleukin (IL)) release. As a result, your muscle soreness, fever, or joint pain is gone.

CBD is also revealed to induce T-cell apoptosis (self-destruction), leading to decreased inflammation in animal and human models. This effect is achieved through CBD interaction with CB1 and CB2, which are the primary receptors cannabinoids bind to.

Additionally, CBD acts as a powerful antioxidant. It disrupts free radicals production (metabolism byproducts, also involved in chronic inflammation).

Top 5 Best CBD Oils for inflammation Reviews

  • 1. Hemplucid Full-Spectrum CBD
    icon product Recommended
    Hemplucid Full-Spectrum CBD for inflammation
    Hemplucid Full-Spectrum CBD
    CBD Type: Full-spectrum
    CBD Potency: 250-1500 mg
    Size: 30 ml
    • Certified
    • Lab-tested
    • Non-intoxicating
    • You can add it to beverages
    • Certified
    • Lab-tested
    • Non-intoxicating
    • You can add it to beverages
    Price range: $29.95 - $119.95
    Copied: DOPECOM Get a deal
    Hemplucid brings lots of superlative CBD products, but its water-soluble CBD makes a big difference. Your body absorbs water-soluble CBD several times faster than traditional cannabidiol due to nanoemulsion. Combined with a full-spectrum hemp formula, nano emulsified CBD brings instant inflammation relief.

    Additionally, Hemplucid’s application of supercritical CO2 hemp extraction ensures organic and non-intoxicating CBD formulas.

    Suggested use: start with 10-12 mg of CBD daily and increase your daily intake to reach a comfortable dosage.
  • 2. Nuleaf Full Spectrum Hemp CBD Oil (60mg/mL)
    Nuleaf Full Spectrum Hemp CBD Oil for inflammation
    Nuleaf Full Spectrum Hemp CBD Oil (60mg/mL)
    CBD Type: Full-spectrum
    CBD Potency: 300-6000mg
    Size: 30ml
    • Colorado-grown hemp
    • Lab-tested products
    • Free shipping
    • Discounts available
    • Colorado-grown hemp
    • Lab-tested products
    • Free shipping
    • Discounts available
    Price range: $38.50 - $439
    Copied: VALIDCBDOIL Get a deal
    Nuleaf Naturals produces CBD with eco-friendliness and safety in mind. Thus, this company grows hemp in the US, uses CO2 extraction, and regularly undergoes independent product laboratory testing. Nuleaf Naturals’ full-spectrum hemp formulation ensures maximum CBD efficiency.

    Additionally, you will receive an additive-free, 100% organic product. Finally, Nuleaf full-spectrum CBD comes in light-defense recyclable bottles that prevent CBD from deteriorating under ultraviolet light exposure.

    Suggested use: 20-30 mg CBD daily is a good starting point.
  • 3. CBDistillery Full Spectrum CBD Oil Tincture
    CBDistillery Full Spectrum CBD Oil Tincture for inflammation
    CBDistillery Full Spectrum CBD Oil Tincture
    CBD Type: Full-spectrum
    CBD Potency: 1000 mg
    Size: 30 ml
    • Certified and lab-tested
    • 60-day money-back guarantee
    • Non-GMO products.
    • Certified and lab-tested
    • 60-day money-back guarantee
    • Non-GMO products.
    Price range: $70
    CBDistillery aims to bring ultimate health balance to its customers. The company achieved this goal through natural cultivation and processing practices and superlative quality control approaches.

    CBDistillery full-spectrum CBD is safe, organic, lab-tested, and efficient: flavonoids, terpenes, and essential cannabinoids enhance CBD properties.

    Suggested use: take 30-60 mg of CBD daily. Start with lower dosing and increase your CBD intake to achieve the best results.

CBD Oil Benefits for Inflammation

So what is best for inflammation? Is it CBD or a common anti-inflammatory drug? As we mentioned before, CBD indeed decreases chronic inflammation. But most importantly, it has several benefits over conventional anti-inflammatory medications like aspirin and ibuprofen. Here they are:


First and foremost, CBD is much safer than traditional anti-inflammatory drugs. Thus, aspirin causes your stomach to produce more acid, involving irritation. Furthermore, it can lead to stomach cramps.

Besides, aspirin (or acetylsalicylic acid) is very aggressive by nature, damaging your intestine and stomach lining, leading to erosion and even ulcers. Ulcers are holes in your stomach: bleeding, unbearable pain, and even death are involved. In contrast to aspirin, CBD doesn’t involve any complications. You can use it for a long time without developing tolerance, addiction, or adverse side effects.


CBD’s safety makes it a far superior treatment for inflammation. Still, cannabidiol brings a lot more than that.

Additional CBD Benefits

CBD can reduce pro-inflammatory cytokines, thus combating inflammation. At the same time, it has a wide array of other health benefits that indirectly decrease inflammation. Thus, CBD:

  • Brings your sleep back to normal.
  • Reduces anxiety and depression.
  • Protects your central nervous system, reducing neuroinflammation.

How do improved sleep and good mood relate to inflammation? The matter is that researchers associate sleep disturbance with increased inflammation. By combating sleep disorders, depression, and anxiety, CBD eliminates inflammation development risks linked to these conditions. Given that, cannabidiol shows both direct and indirect anti-inflammatory effects.

CBD Oil vs CBD Tinctures: What’s Better?

Aren’t CBD oils and tinctures the same thing? In reality, these are two different products. CBD oil is a super-potent and effective liquid made with supercritical CO2 hemp extraction. On the other side, a CBD tincture is made by infusing cannabidiol with alcohol.

The latter brings some unpleasant properties to the tincture. First, it makes the mixture taste bitter. Second, it can cause chemical burns if you hold it under your tongue, making the most effective CBD administration method (the sublingual one) harmful.

As a result, you should always opt for the best oil for inflammation, not tinctures. Nonetheless, many CBD brands label their oils as tinctures, but these products might not necessarily contain alcohol. Consequently, you should read CBD product descriptions and avoid the “true” tinctures (those containing alcohol).

How to Take CBD for Inflammation?

CBD dosing is always individual: there is no prescribed dose for everyone. The best thing you can do is consult your doctor to decide on the best CBD dosage for your condition. Once you determine the initial CBD intake, you can lower or increase it slowly to achieve inflammation and pain relief. What is a typical starting CBD dose? For mild conditions, you can begin with 10-15 mg CBD per day.

leaf min leaf mid leaf max
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CBD Dosage Calculator

Experience Level with CBD
  • None - Mild
  • Medium
  • Severe
Total Body Weight (in lbs)
  • < 45
  • 46-86
  • 86 - 150
  • 151-240
  • >240
  • <45
  • 46 – 85
  • 86 – 150
  • 151-240
  • >240
  • <45
  • 46-85
  • 86-150
  • 151-240
  • >240
this calculator is for informational purposes only. Talk with your Doctor before taking CBD. Individual results may vary.

What’s the best time to take CBD?

In the case of CBD oils and tinctures, the sublingual application is your best choice. When you take CBD under your tongue, your sublingual gland absorbs it and allows it to enter your bloodstream, avoiding the digestive system. Given that, you can take cannabidiol regardless of your meal plan. Plus, you will achieve faster relief.

How to Choose Best CBD for Inflammation?

You have already read about five brands in our review. There are hundreds of other companies out there, and each of them applies different approaches to hemp cultivation and CBD production. Due to this, CBD quality differs a lot from brand to brand. How to choose the right product then? Check these tips on selecting the best CBD oil for inflammation:

  • Take a look at THC content. A CBD product must contain no more than 0.3% THC. Tetrahydrocannabinol (THC) is a psychoactive ingredient found in marijuana. In short, this component makes people high when they smoke weed. Keeping THC content within 0.3% allows brands to get the utmost advantage of their CBD products without compromising their clients’ health.
  • Check whether hemp is grown in the US or Northern Europe. European and American companies produce CBD of the highest quality due to strict hemp regulation standards.
  • Pay attention to CBD strength. If you have a mild condition, you don’t need to buy super-potent oil with 100 mg CBD per milliliter. It’s because you can get relief from smaller doses, and purchasing a strong product will only complicate daily dosing.
  • Check for licenses and laboratory tests. Reviewing your product’s certificate of analysis is crucial.
  • Always compare prices. CBD costs a lot and neglecting discounts or more reasonable offers can drain your budget.

Final Thoughts

CBD’s inflammation reduction mechanisms are not only evident but also well-studied. Given that, cannabidiol can complement your current treatment or even become an independent solution. You can take CBD for skin problems, joint pain, shingles, heart diseases, fever, and other conditions involving inflammation.

Most importantly, CBD brings balance to your body and doesn’t involve severe side effects like conventional anti-inflammatory medications. Therefore, taking CBD is a real chance to make your life a bit better. To get fast and consistent relief, you should opt for reputable, certified, and tested American or European CBD brands.


How does CBD Reduce Inflammation?

CBD reduces inflammation by decreasing pro-inflammatory markers release. Additionally, CBD breaks chemical reactions that produce free radicals and helps your body remove them. Finally, CBD soothes the nervous system, promotes better sleep, and alleviates anxiety, contributing to mechanisms that naturally reduce inflammation in your body.

Which CBD is Best for Inflammation?

You can apply CBD cream on your knee for joint inflammation, for example. However, the topical application might not always be suitable for other inflammation types. In this case, CBD oil becomes the best option since it targets the entire body and lowers systemic inflammation.

What is Best for Chronic Inflammation?

Treatment consistency is the key to reducing chronic inflammation. For this, you need to take CBD at the same time every day for a month or longer (depending on your condition) to get consistent relief. Plus, you should sleep well, eat healthy food, and exercise several times a week.

Article Sources
Written by:

Jamie Taylor

Jamie has more than ten years of experience as a physician assistant. He has always been interested in the healing potential of cannabidiol, especially in its pain relief properties. Jamie considers cannabidiol as a powerful remedy with minimal side effects. He knows how to help users make rational buying decisions based on the unbiased and accurate reviews of CBD products and brands.

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